Eric A Hoffman, PhD
Education
1969 - 1970
- Tulane University, New Orleans, LA
1970 - 1974
- BA, Physiological Psychology, Antioch College, Yellow Spring, OH
1971 - 1972
- Psychology, University of Southampton, England
1975 - 1981
- PhD, Physiology, University of Minnesota / Mayo Graduate School of Medicine, Rochester, MN
1974 - 1975
- Research Assistant, Cardiovascular Pulmonary Research Laboratory, University of Colorado, Denver, CO
Summer of 1975
- Research Assistant, Department of Physiology & Biophysics, Colorado State University, Fort Collins, CO
1975 - 1981
- Pre-doctoral Research Fellow, Physiology, Biodynamics Research Unit, Mayo Foundation, Rochester, MN
1981 - 1982
- Fellowship, Physiologic Imaging, Department of Physiology and Biophysics, Mayo Foundation, Rochester, MN
1983 - 1984
- Senior Fellowship, Physiologic Imaging, Department of Physiology and Biophysics, Mayo Foundation, Rochester, MN
1982 - 1984
- Instructor of Physiology, Mayo Medical School, Rochester, MN
1984 - 1987
- Assistant Consultant, Department of Physiology and Biophysics, Mayo Foundation, Rochester, MN
1984 - 1987
- Associate Consultant, Department of Physiology and Biophysics, Mayo Foundation, Rochester, MN
1987 - 1990
- Assistant Professor of Radiologic Science and Physiology, University of Pennsylvania, Philadelphia, PA
1987 - 1991
- Director of Research, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA
1988 - 1992
- Staff of the Hospital of the University of Pennsylvania, Philadelphia, PA
1988 - 1992
- Chief, Imaging Research, Department of Radiology, University of Pennsylvania, Philadelphia, PA
1990 - 1992
- Associate Professor fo the Radiologic Science and Physiology, University of Iowa, Iowa City, IA
1992 - 1996
- Associate Professor of Radiology and Physiology, University of Iowa, Iowa City, IA
1992 - Present
- Director of Advanced Pulmonary Physiomic Imaging Laboratory, Department of Radiology, University of Iowa, Iowa City, IA
1995 - Present
- Member and Co-director of Executive Committee, Environmental Health Sciences Research Center, Human Exposure Chamber
1996 - Present
- Professor of Radiology and Biomedical Engineering, University of Iowa, Iowa City, IA
2004 - 2013
- Director, Iowa-Comprehensive Lung Imaging Center, University of Iowa, Iowa City, IA
2006
- Professor of Medicine, University of Iowa Carver of Medicine, Iowa City, IA
2013 - Present
- Director, Advanced Pulmonary Physiomic Imaging Laboratory: APPIL, University of Iowa, Iowa City, IA
Education/Training Program Affiliations
- Biosciences Graduate Program
- Interdisciplinary Graduate Program in Infomatics
- Interdisciplinary Graduate Program in Translational Biomedicine
- Medical Scientist Training Program
Academic Appointments
1975
- Research Associate, Cardiovascular Pulmonary Research, University of Colorado Medical School, Denver, Colorado
1975 - 1981
- Pre-doctoral Research Fellow, Biodynamics Research Unit, Mayo Foundation
1981 - 1982
- Research Fellow, Biodynamics Research Unit, Department of Physiology and and Biophysics, Mayo Foundation
1982 - 1984
- Instructor in Physiology, Mayo Medical School
1984 - 1987
- Assistant Professor of Physiology, Mayo Medical School
1987 - 1990
- Assistant Professor of Radiologic Science and Physiology, University of Pennsylvania School of Medicine
1990 - 1992
- Associate Professor of Radiologic Science and Physiology, University of Pennsylvania School of Medicine
1992 - 1996
- Associate Professor of Radiology and Phsiology, University of Iowa, Iowa City, Iowa
1996 - Pres.
- Professor of Radiology, Medicine and Biomedical Engineering, University of Iowa, Iowa City, Iowa
Honors and Patents
1983 - 1986
- New Investigator Award, National Heart, Lung and Blood Institute
1983 - 1986
- John G. Searl, Mayo Scholar
1984 - Pres.
- Sigma XI (Fellow)
1985
- Correspondent in Gravitational Physiology, the International Union of Physiological Sciences Commission of Gravitation Physiology
1986 - 1991
- Established Investigator of the American Heart Association
1987
- The 1987 Outstanding Film Award, American College of Chest Physicians: Hoffman, EA, Ritman, EL, Intra-Cardiac Cycle constancy of Total Heart Volume
1987
- Research Career Development Award, National Institutes of Health (decline because of conflict with AHA Established Investigator Award)
1987
- Inducted: Fellow of College of Fellows: American Institute for Medical and Biological Engineering (AIMBE)
1987
- New Horizon's Lecturer and Honorary Member of Society of Thoracic Imaging
1990 - 1993
- Ethel Brown Foerderer Fund Fellow (in recognition of excellence in the field of Cardiovascular Imaging) Children’s Hospital of Philadelphia
1990 - 1994
- Member, NIH Biomedical Research Technology study section
1994 - 1995
- Ethel Brown Foerderer Fund Fellow (in recognition of excellence in the field of "Functional and 3-D Pulmonary Imaging with Spiral Computer Tomography—CT")
1996
- National Information Infastructure Semi Finalist Award for "Welcome to Physiologic Imaging" (http://everest.radiology.uiowa.edu)
2000
- Inducted as a Fellow into the College of Fellows of the American Institute for Medical and Biological Engineering (AIMBE)
2002 - 2014
- Deputy Editor: Academic Radiology
2003
- Herbert M. Stauffer, Outstanding Basic Science Paper: Tajik JK, Chon D, Won C, Tran BQ, Hoffman EA. Subsecond multisection CT of regional pulmonary ventilation Acad Radiol 2002, 9(2): 130-146
2004
- Herbert M. Stauffer, Outstanding Basic Science Paper. Meinel JF Jr, Wang G, Jiang M, Frei T, Vannier M, Hoffman EA. Spatial variation of resolution and noise in multi-detector row spiral CT. Acad Radiol 2003;10(6):607-613
2005
- Inducted as a member of the Fleichner Society for Thoracic Imaging and Diagnosis
2005 - Pres.
- Fellow of American Heart Association (FAHA)
2006 - 2010
- Standing Member of NIH "Respiratory Integrative Biology and Translational Research" study section (RIBT).
2007
- Herbert M. Stauffer, Outstanding Basic Science Paper: Easley RB, Fuld MK, Fernandez-Bustamante A, Hoffman EA, Simon BA. Mechanism of hypoxemia in acute lung injury evaluated by multidetector-row CT. Acad Radiol 2006, Jul;13(7):916-21.
2007 - 2010
- NIH Study Section Member: RIBT
2012
- Respiratory Physiology and Neurobiology 2012 award for top 10 most cited papers of 2006-2010. Characteristic of the turbulent laryngeal jet and its effect on air flow in the human intrathoracic airways
2013
- John West award "for outstanding contributions to the field of functional pulmonary imaging": International Workshop for Pulmonary Functional Imaging (IWPFI).
2014
- Joseph R. Rodarte Award "for scientific distinction": ATS Assembly on Respiratory Structure & Function
2015
- Fellow of the European Respiratory Society "in recognition of excellence in scientific and/or educational contributions to respiratory medicine over many years" (FERS)
2018
- Fellow of the American Thoracic Society (ATSF)
2018
- Distingushed Investigator Award, The Academy of Radiology & Biomedical Imaging Research
2018
- The 33rd Annual Alton Ochsner Award Relating Smoking and Disease "Internationally recognized for his work with advanced imaging methodologies that address mechanisms of lung diseae resulting from tobacco comsuption"
10/15/2002
- Method and Apparatus for Analyzing CT Images to Determine the Presence of Pulmonary Parenchyma: Renuka Uppaluri: Eric A. Hoffman, Theophano Mitsa, Milan Sonka, and Geoffrey McLennan, Patent Number 6,466,687 B1
03/01/2004
- Bioluminescent CT method and apparatus. Ge Wang, Eric A. Hoffman, Geoffrey McLennan: Patent disclosure filled in July 2002; US provisional patent application filled in March 2003; US patent application (U.S. No.60/453,177) filed in March 2004
02/12/2004
- Methods and devices useful for analyzing color medical images. Geoffrey McLennan, Martin Donnelley, Deepa Gopalakrishnan, Eric A. Hoffman, Joseph Reinhard and Melissa Suter: U.S. Patent Application No. 10/777,764. Filed February 12, 2004
02/14/2005
- Methods for smoothing segmented regions. Joseph M. Reinhardt, Soumik Ukil, Milan Sonka, Geoffrey McLennan, and Eric A. Hoffman, U.S. Provisional Patent Application No. 60/652,695. Filed February 14, 2005
05/05/2005
- Methods and devices for labeling and/or matching. Juerg Tschirren, Milan Sonka, Geoffrey McLennan, Eric A. Hoffman, and Joseph Reinhardt, U.S. Patent Application No. 11/122,974. Filed May 5, 2005
10/26/2006
- Treatment Planning Methods, Devices, and Systems. John R. Weis, Joseph Reinhardt, John Garber, Juerg Tschirren, Milan Sonka, Geoffrey McLennan, and Eric A. Hoffman, U.S. Patent Application No. 11/542,016, Filed October 26, 2006
04/30/2007
- Methods and Apparatuses for Analyzing Images. Renuka Uppaluri, Theophano Mitsa, Eric A Hoffman, Geoffrey McLennan, and Milan Sonka, U.S. Patent Application No. 10/251,446. Filed September 20, 2002
05/05/2010
- Methods for Multi-Scale Meshing of Branching Biological Structures. Merryn H. Tawhai, Eric A. Hoffman, Ching-Long Lin. Patent Number US2011/0093243. Filed May 5, 2010
05/11/2010
- Compositions and Methods for Enhancing Contrast in Imaging. Ananth Annapragada, Rivi V. Bellamkonda, Eric A. Hoffman, Chandra Vijayalakshmi. Patent No. Us7,713,517. Filed April 21, 2004.
02/08/2011
- Methods and Apparatuses for Analyzing Images. Renuka Uppaluri, Theophano Mitsa, Eric A. Hoffman, Geoffrey McLennan, and Milan Sonka, U.S. Patent No. US7,885,438 B2. Feb. 8, 2011
12/06/2011
- Methods of Smoothing Segmented Regions and Related Devices. Joseph Reinhardt, Milan Sonka, Geoffrey McLennan, Eric A. Hoffman, Soumik Ukil, and Steven L. Highlander, U.S. Patent US8,073,210 B2. Dec. 6, 2011
01/03/2012
- Systems and Methods for Bioluminescent Computed Tomographic Reconstruction. Ge Wang, Eric A. Hoffman, Geoffrey McLennan. Patent number US8,090,431 B2. Filed March 2, 2004.
05/11/2020
- Regional pulmonary V/Q via image registration and multi-energy CT. Eric A. Hoffman, Seyed Mohammad Amin Motahari Bidgoli, Chanaghyun Lee, Joseph Marion Reinhardt. Filed November 5, 2020.
02/02/2021
- Systems and methods for airway tree segmentation. Punam Kumar Saha, Eric A. Hoffman, Syed Ahmed Nadeem Patent number US10,909,684 Filed November 19, 2018
Research Summary
Eric A. Hoffman, PhD is a professor of radiology, medicine and biomedical engineering at the University of Iowa. He is the director of the Advanced Pulmonary Physiomic Imaging Laboratory (APPIL) in the Department of Radiology and the director of the Iowa Comprehensive Lung Imaging Center (I-Clic) at the University of Iowa. He received his Ph.D. in Physiology from the University of Minnesota / Mayo Graduate School of Medicine in 1981 and remained on staff at the Mayo Clinic where he was a member of the team which Developed the Dynamic Spatial Reconstructor (DSR), a one of a kind CT scanner which was able to gather up to 240 contiguous CT sections of the body every 1/60 second. Throughout his career he has used advanced imaging methodologies to study basic respiratory physiology centered largely on mechanisms of ventilation and perfusion heterogeneity and regional lung mechanics. Dr. Hoffman moved from the Mayo Clinic in 1987 to head the Cardiothoracic Imaging Research Center in the Department of Radiology at the University of Pennsylvania and then moved in 1992 to his current position at the University of Iowa. Most recently, in addition to continuing basic physiologic research of the lung, he has established a combination of single and multi-spectral multidetector row spiral CT imaging methodology to objectively follow human lung pathology and pathophysiology with a particular emphasis on inflammatory lung diseases. The centerpiece of APPIL is a Siemens SOMATOM Force CT scanner.
Dr. Hoffman is the author of more than 570 journal articles and 21 book chapters in the field of dynamic volumetric imaging of the lung and heart and served for 5 years as the founding chair of the Physiology and Function from Multidimensional Imaging sessions of the SPIE Medical Imaging conference. Dr. Hoffman was inducted into the college of fellows of the American Institute for Medical and Biological Engineering in March of 2000 and was elected into the Fleischner Society in May 2005 and named a Distinguished Investigator by The Academy for Radiology and Biomedical Imaging Research in 2018. He received the 2013 John West award for Outstanding Contributions to the Field of Functional Pulmonary Imaging from the IWPFI, the 2014 Joseph R Rodarte Award for Scientific Distinction from the Respiratory Structure and Function Assembly of the American Thoracic Society and the 2018 Alton Ochsner Award "relating smoking and disease." He is a fellow of the European Respiratory Society and the American Thoracic Society. Dr. Hoffman's laboratory is dedicated to the use of advanced imaging methodologies for the exploration of normal and pathologic physiology of the lung with specific areas of interest relating to inflammatory lung diseases including COPD, Astham and environmentally induced pathologies. APPIL serves as the Radiology Center for numerous large multi-center studies utilizing imaging to phenotype the lung as a component of the study (including SPIROMICS, MESA Lung, SARP, PreCISE, British Lung Foundation Early COPD)
Contributions
Dr. Eric A. Hoffman, Ph.D. was a member of the team at the Mayo Clinic which, in the mid-late 1970's developed the Dynamic Spatial Reconstructor (DSR), a one of a kind CT scanner which was able to gather up to 240 contiguous CT sections of the body every 1/60 second. Through his career, Dr. Hoffman has used advanced imaging methodologies to study basic respiratory physiology centered largely on mechanisms of ventilation and perfusion heterogeneity and regional lung mechanics. His earliest publication served to define the role of the H1 and H2 (histamine) receptors in the lung and in the mid to late 1970's he performed biplane video fluoroscopy studies to provide insights into lung mechanics with the assessment of gradients in pleural surface forces (pleural pressure). Also in the late 1970's volumetric computed tomography was used to provide a first look at regional lung mechanics in the never invaded negative pressure environment of the intact thorax.
- E.A. Hoffman, M.L. Munroe, A. Tucker, J.T. Reeves. Histamine H1- and H2-receptors in the cat and their roles during alveolar hypoxia. Respiratory Physiology 197 May; 29(3):255-264. PubMed PMID: 882726.
- E.A. Hoffman, T. Behrenbeck, P.A. Chevalier, and E.H. Wood. Estimation of regional pleural surface expansile forces in intact dogs. Journal of Applied Physiology: Respiratory, Environmental, and Exercise Physiology 1983; 55(3):935-948. PubMed PMID:6355027.
- E.A. Hoffman, L.J. Sinak, R.A. Robb, and E.L. Ritman. Noninvasive quantitative imaging of shape and volume of lungs. Journal of Applied Physiology: Respiratory, Environmental, and Exercise Physiology 1983; 54(5):1414-1421. PubMed PMID:6863100.
- E.A. Hoffman and E.L. Ritman. Shape and dimensions of cardiac chambers: importance of CT section thickness and orientation. Radiology 1985; 155(3): 739-744. PubMed PMID:4001378
Early observations with dynamic volumetric CT of the heart and lung served to demonstrate that gradients in regional lung expansion in the supine lung were not simply a function of gravity because the gradient was nearly eliminated, not just reversed , in the prone body posture. Comparative studies of dogs and sloths lead to the notion that support of the heart by the lung contributes to regional differences in lung expansion. Cardiac investigations demonstrated that the total volume of the heart (contents of the the pericardial sac) remains relatively constant throughout the cardiac cycle with the atria filling while the ventricles empty and the fluid filled pericardial sac buffering shape changes, allowing the heart to expend it's energy pumping blood and protecting the lung from large intra-thoracic volume changes. It was demonstrated that the constant heart volume relationship was disrupted by atrial fibrillation as atrial wall stiffness added to ventricular afterload as the descent of the atrial valve plane met increased resistance.
- E.A. Hoffman. Effect of body orientation on regional lung expansion: computed tomographic approach. Journal of Applied Physiology 1985; 59(2): 468-480. PubMed PMID: 4030599.
- E.A. Hoffman and E.L. Ritman. Effect of body orientation on regional lung expansion in dog and sloth. Journal of Applied Physiology 1985; 59(2): 481-491. PubMed PMID: 4030600.
- E.A. Hoffman and E.L. Ritman. Invariant total heart volume in the intact thorax. American Journal of Physiology: Heart and Circulatory Physiology 1985; 249:H883-H890. PubMed PMID: 4051023.
- Hoffman EA and E.L. Ritman. Heart-lung interaction: Effect on regional lung air content and total heart volume. Annals of Biomedical Engineering 1987; 15(3-4):241-257. PubMed PMID: 3662146.
Other early works included imaging-based assessments of the upper airway in obstructive sleep apnea, the cholinergic and adrenergic response of the bronchial tree, further investigation of mechanical interactions between the heart and lung. From the expansion of the early works, Hoffman's contributions have served to illuminate many underlying relationships in both COPD, Asthma and Cystic Fibrosis with key findings demonstrating that smokers susceptible to centriacinar emphysema demonstrate increased heterogeneity of perfusion, CF is characterized by a tethering of extruded mucous and COPD subjects have thinned, not thickened, airways if one accounts for spatial location within the airway tree.
- S. Alford, E.J. van Beek, G. McLennan, E.A. Hoffman. Heterogeneity of Pulmonary Perfusion in Lung Disease: Phenotyping COPD by Multi-Detector Row CT. Proceeding of the National Academy of Sciences of the United States of America. Proc Natl Acad Sci USA. 2010 Apr 20:107(16):7485-90. PubMed PMID:20368443; PubMed Central PMCID: PMC2867701.
- B.M. Smith, E.A. Hoffman, D. Rabinowitz, E. Bleecker, S. Christenson, D. Couper, K.M. Donohue, M.K. Han, N.N. Hansel, R.E. Kanner, E. Kleerup, S. Rennard, R.G. Barr. Comparison of spatially matched airways reveals thinner airway walls in COPD The Multi-Ethnic Study of Atherosclerosis (MESA)COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax. 2014 Nov;69(11):987-96. PubMed PMID:24928812; PubMed PMCID: PMC4213995.
- E.A. Hoffman, F.S. Ahmed, H. Baumhauer, M. Budoff, J.J. Carr, R. Kronmal, S. Reddy, R.G. Barr. Variation in the percent of emphysema-like lung in a healthy, nonsmoking multiethnic sample. The MESA lung study. Ann Am Thoracic Soc. 2014 Jul;11(6):898-907. doi: 10.1513/AnnalsATS.201310-364OC. PMCID:PMC4213995.
- M.J. Hoegger, M. Awadalla, E. Namati, O.A. Itani, A.J. Fischer, A.J. Tucker, R.J. Adam, G. McLennan, E.A. Hoffman, D.A. Stoltz, M.J. Welsh. Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs. Proc Natl Acad Sci USA. 2014 Feb 11;111(6) :2355-60. doi: 10.1073/pnas. 1323633111. Epub 2014 Jan 28. PubMed PMID: 25124441; PubMed Central PMCID: PMC4346163.
In addition to direct assessment of lung physiology and pathophysiology, Hoffman's imaging work (always targeting the understanding of biological phenomena) has led to collaborations seeking to use the dynamic 3D lung images to model fluid dynamics in health and disease.
- S. Choi, E.A. Hoffman, S.E. Wenzel, M. Castro, C.L. Lin. Improved CT-based estimate of pulmonary gas trapping accounting for scanner and lung-volume variations in a multicenter asthmatic study. J Appl Physiol (1985). 2014 Sep 15;117(6):593-603. doi: 10.1152/japplphysiol.00280.2014. Epub 2014 Aug 7. PubMed Central PMCID: PMC4157164.
- C.L. Lin, M.H. Tawhai, E.A. Hoffman. Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs. Wiley Interdisciplinary Rev Syst Biol Med. 2013 Sep-Oct;5(5):643-55. doi: 10.1002/wsbm.1234. Epub 2013 Jul 10. Review. PubMed Central PMCID: PMC3763693.
- K.S. Burrowes, E.A. Hoffman, M.H. Tawhai. Species-specific pulmonary arterial asymmetry determines species differences in regional pulmonary perfusion. Ann Biomedical Eng. 2009 Dec; 37(12):2497-509. doi: 10.1007/s10439-009-9802-2. Epub 2009 Sep 19. PubMed PMID: 19768544; PubMed Central PMCID: PMC3056879.
Hoffman's laboratory has recently devised micro CT imaging methods applied to the intact mouse lung to quantitatively assess structure down to the alveolar level of young and old mouse lungs. Dr. Hoffman's recent work has led him to the investigation of vascular dysfunction in the etiology of emphysema based upon novel uses of dual energy multidetector row CT (DECT). A key contribution of Dr. Hoffman's work lies in the continued efforts to provide quantitative imaging tools for use in multi-center studies seeking to phenotyping of the normal and diseased lung.
- D. Chon, K.C. Beck, B.A. Simon, H. Shikata, O.I. Saba, E.A. Hoffman. Effect of low-xenon and krypton supplementation on signal/noise of regional CT-based ventilation measurements. J Appl Physiol. 2007; Apr; 102(4):1535-44.
- M.K. Fuld, A.F. Halaweish, J.D. Newell Jr, B. Krauss, E.A. Hoffman. Optimization of Dual-Energy Xenon-Computed Tomography for Quantitative Assessment of Regional Pulmonary Ventilation. Investigative Radiology. 2013 Sept; 48(9):629-37. PMC3873149.
- M.K. Fuld, A.E. Halaweish, S.E. Haynes, A.A. Divekar, J. Guo, E.A. Hoffman. Pulmonary Perfused Blood Volume with Dual-Energy CT as Surrogate for Pulmonary Perfusion Assessed with Dynamic Multidetector CT. Radiology. 2013 Jun;267(3):747-56. PMC3662901.
- D. Vasilescu, Z. Gao, E.R. Weibel, E.A. Hoffman. Assessment of Morphometry of Pulmonary Acini in Mouse Lung by Nondestructive Imaging using Multi-Scale Microcomputed Tomography. Proc Natl Acad Sci USA. 2012 October 16; 109(42): 17105-17110. Epub 2012 October 1. PMC3479519.
Ongoing Research Support
- 2012/08/01-2016/12/31
- 5R01HL112986, NIH/NHLBI
- Hoffman, Eric(PI)
- Multi-Center Structural & Functional Quantitative CT Pulmonary Phenotyping
- This proposed bioengineering research partnership seeks to take advantage of the emerging acquisistion technique of multi-spectral computed tomography (currently dual energy CT:DECT), careful evaluation of dose lowering methods, and novel approaches to statistical cluster analysis to expand the biomarkers used in multi-center studies to identify subpopulations of lung disease.
- Role: Principal Investigator
- 2009/02/01-2016/01/31
- HHSN268200900013C, Department of Health and Human Services
- SPIROMICS Radiology Center
- The objective of the Radiology Center for SPIROMICS is to propose and oversee the acquisition of state-of-the-art CT image data sets needed for the provision of lung phenotypes associated with COPD to facilitate genotype correlation, and which can serve as the baseline for the assessment of outcomes in COPD interventions.
- Role: Principal Investigator
- 2015/04/15-2019/03/31
- 1R01HL126838, NIH/NHLBI
- Hoffman, Eric(PI)
- Defining the Role of Early Pulmonary Vascular Disease in COPD
- This project evaluates the role of imaging-based measures of pulmonary vascular structure and function to identify smokers at risk of rapid emphysema progression and/or at risk of having frequent acute exacerbations of their COPD.
- Role: Principal Investigator
- 2007/070/1-2017/07/13
- 5R01HL089897, NIH/NHLBI
- Crapo(PI)
- (1 of 2) Genetic Epidemiology of COPD
- The major goal of this project is to develop an imaging protocol for comparative analysis and carry out airway wall thickness quantifications from CT scans in collaboration with National Jewish Imaging Center.
- Role: Principal Investigator - Iowa Subaward
- 2014/08/01-2018/04/30
- 1R01HL120270, NIH/NHLBI
- Barr(PI)
- Novel Quantitative Emphysema Subtypes in MESA and SPIROMICS
- The primary goals of this project are to develop novel and robust image processing tools for the extraction of emphysema radiological features on CT scans, perform unsupervised clustering of emphysema radiological features on the large MESA cohort of patients to discover quantitative emphysema subtypes (QES), and to quantify the levels of normality for QES among homogeneous populations of non-smoking "normal" participants without respiratory symptoms and disease.
- Role: Principal Investigator - Iowa Subaward
- 2008/08/28-2018/01/31
- 2R01HL093081, NIH/NHLBI
- Pulmonary Microvascular Blood Flow and Cor Pulmonale Parvus in Emphysema/COPD
- The major goal of this project is to accept and upload CT images from the four MESA-COPD scanning sites and to analyze them for measures of lung density, perform post- processing of data, and transmit results to the MESA Coordinating Center
- Role: Principal Investigator - Iowa Subaward
- 2008/09/01-2018/06/30
- 5P01HL091842, NIH/NHLBI
- Welsh(PI)
- PPG-Airway Physiology and Pathophysiology in a Porcine CF Model
- This project aims to discover how loss of CFTR function affects mucociliary transport, response of airways to viral invention, HC03-secretion and control of airway surface liquid pH, and bacterial killing of the airway surface.
- Role: Co-Investigator
- 2011/08/08-2017/05/31
- 5U01HL109257, NIH/NHLBI
- Castro(PI)
- Severe Asthma Research Program (SARPIII) - Washington University
- The major goal of this project is to serve as the data archive and analysis site for the SARP.
- Role: Principal Investigator - Iowa Subaward
- 2013/08/15-2018/05/31
- 5U01HL114494, NIH/NHLBI
- Lin(PI)
- An Integrative Statistics-Guided Image-Based Multi-Scale Lung Model
- Theis project aims to build a new computational framework for assessment and prediction of lung function through integration of statistical analysis of population data with prediction of function in individual subjects via a multi-scale computational fluid dynamics (CFD) lung model, for improved patient phenotyping and patient-specific therapy.
- Role: Co-Investigator
- 2014/05/05-2018/04/30
- 1R01HL122438, NIH/NHLBI
- Han(PI)
- Parametric Response Mapping in COPD
- Chronic Obstructive Pulmonary Disease (CODP) is a highly prevalent but heterogeneous disorder with varying clinical presentations and rate of progression. Current disease staging and therapy is based only on spirometry and clinical characteristics. Thoracic imaging holds promise for characterizing COPD heterogeneity and identifying early disease, but standard techniques are limited by their inability to resolve emphysema and small airways disease.
- Role: Principal Investigator - Iowa Subaward
- 2011/08/08-2017/05/31
- 5U01HL109168, NIH/NHLBI
- Jarjour(PI)
- Stability of Severe Asthma Phenotypes: Impact of Exacerbations (SARP III)
- The major goal of this project is to serve as the data archive and analysis site for the SARP.
- Role: Principal Investigator - Iowa Subaward
- 2011/08/09-2017/05/31
- 5U01HL109152, NIH/NHLBI
- Wenzel(PI)
- Implications and Stability of Clinical and Molecular Phenotypes of Severe Asthma (SARP III)
- The major goal of this project is to serve as the data archive and analysis site for the SARP.
- Role: Principal Investigator - Iowa Subaward
- 2015/02/17-2016/02/16
- 1S10OD018526-01, NIH/NHLBI
- Hoffman, Eric(PI)
- Ultra-low Dose, High Seed, High Resolution, Multispectral, Multi-Source MDCT Scanner
- This high-end shared instrumentation grant allow for the upgrade of the current Siemens Flash to a Simens Force CT scanner. The new scanner will allow for scanning at as low as 10% of the current radiation dose. It will allow for a 30% reduction in iodine contrast agent, imaging of regional ventilation with krypton rather than xenon gas or with xenon gas at a large reduction in concentration. Both of these allow for the elmination of the anesthetice side effect of Xenon. In addition, the scanner will have up to 2-3 times the spatial resolution, providing the details needed to truly assess airway remodeling in COPD and Asthma.
- Role: Principal Investigator
- 2015/03/29-2016/03/30
- 5P30ES005605, NIEHS
- Thorne(PI)
- EHSRC Pilot Grant - Correlation of Pulmonary Structural and Functional Alterations in a Population Exposed to Indoor Cooking with Solid Biolfuels/Hutt Lung
- This project is focused on a pilot cohor of subjects in India for which a large amount of data will be collected including demographic/health questionnaires, computed tomography, pulmonary function testing, in home air quality measures, and biological samples.
- Role: Principal Investigator - Pilot Award
- 2015/07/01-2016/06/30
- 1S10OD018503, NIH/OD
- Sieren(PI)
- Non-Destructive Multi-Scale Micro-CT Imaging System
- This application seeks to obtain a nondestructive mulit-scale micro-CT imaging system, the Zeiss Xradia VersaXRM-520 to fill a research technology void at the University of Iowa.
- Role: Major User
Center, Program and Institute Affiliations
- Cardiovascular Research Center
- Environmental Health Sciences Research Center
- Institute for Clinical and Translational Science
- Iowa Comprehensive Lung Imaging Center (I-CLIC)
- Iowa Institute for Biomedical Imaging