Smoking Cessation Study

Cigarette smokers 21-65 years old are invited to participate in a smoking cessation study. The purpose of this research study is to find out if smoking cessation combined with Sildenafil, will restore blood flow to possible injured areas of your lungs. Sildenafil is an FDA approved medication that is approved for many different uses including the treatment of pulmonary hypertension but it will be given, during this study, in a non FDA-approved manner. You have a 50/50 chance of receiving Sildenafil or placebo.

Your involvement will be four visits over 90 days. The first visit (baseline) last between 5-7 hours. The 30 and 60 day visits will be 2-3 hours, and the last visit will be 4-5 hours.

The study involves filling out questionnaires, lung function (breathing) tests, CT scans with and without contrast; blood draws, a urine sample, and a smoking cessation session. If you complete all study procedures and visits you will be paid $425.

Optional sub-studies:

  1. If you successfully quit smoking and have no detectable levels of tobacco in your blood at 60 and 90 days you will receive $400. Requires one additional tube of blood at each visit.

Smoker Requirements:

  • Current cigarettes smokers that smoke at least one half pack of cigarettes daily.
  • Have a desire to stop smoking.
  • 25-65 years of age.
  • Willing to abstain from using nicotine patches, e-cigarettes, or marijuana for the duration of the study.

Non-Smoker Requirements:

  • Have never smoked (confirmed with cotinine level and CO Smokerlyzer).
  • Be willing to attend all clinic visits.
  • 21-65 years of age.


Interested? Please complete the survey to see if you qualify.

Click Here to take our survey.

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