ATS

Imaging-Based Cluster Analysis Using Novel Metrics in COPD for Sub-Phenotyping of Current Smokers: SPIROMICS.
Haghighi B, Choi S, Choi J, Li F, Hoffman EA, Comellas AP, Newell JD, Barr R, Han MK, Bleecker ER, Cooper CB, Couper D,
Hansel NN, Kanner RE, Kazerooni E, Martinex FJ, O'Neal WK, Paine R, Rennard SI, Woodruff P, Lin C.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med: 2018;197:A1033

Silent Zones of Lung Disease in Active Smokers.
Bodduluri S, Gerard SE, Reinhardt JM, Hoffman EA, Newell JD,Nath HP, Dransfield MT, Bhatt SP.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med: 2018;197:A1034

Association Between Plasma Polyunsaturated Fatty Acids and Subclinical Interstitial Lung Disease: The MESA Study.
Kim J, Steffen B, Podolanczuk A, Kawut S, Raghu G, Hoffman EA, Tsai M, Barr R, Lederer D.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med: 2018;197: A1101

Regional Distribution of High Attenuation Areas on CT in the Multi-Ethnic Study of Atherosclerosis (MESA).
Choi B, Kawut M, Raghu G, Hoffman EA, Tracy R, Madahar P, Bernstein EJ, Barr R, Lederer DJ, Podolanzcuk A.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med: 2018;197:A1616

Mucin-based Metrics to Quantitative and Identify Mucus Component of Peripheral Airways Obstruction in the SPIROMICS Cohort.
Boucher RC, Ceppe AS, O'Neal WK, Ford A, Barr RG, Bleecker ER, Curtis JL, Cooper CB, Han MK, Hoffman EA, Martinez FJ, Paine R, Woodruff P, Smith BM, Kesimer M.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :197; 2018

Allergen Sensitization and Exposure is Associated with Exacerbations in COPD.
Putcha N, Fawzy A, Matsui E, Bowler RP, Woodruff P, O'Neal WK, Comellas AP, Han MK, Dransfield MT, Lugogo N, Hoffman EA, Cooper CB, Hersh CP,Paulin LM, Drummond M, Wise RA, Diette GB, Hansel NN.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Risk Factors and Implications of Bronchiectasis on COPD Severity in the Subpopulations and Intermediate Outcome Measures in COPD Study
Genese F, Ortega VE, Marion CR, O'Neal WK, Newell JD, Barr R, Cooper CB, Couper D, Han MK, Hansel NN, Kanner E, Martinez FJ,
Meyers DA, Woodruff P, Peters SP, Hoffman EA, Bleecker ER.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Characteristics of Inhaled Particle Deposition in the Lungs of Imaged-based Asthma Clusters: A Numerical Study.
Choi J, LeBlanc LJ, Choi S, Haghighi B, Hoffman EA, O'Shaughnessy P. Wenzel SE, Castro M, Fain SB, Jarjour NN, Schiebler ML, Denlinger LC, Lin C.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Air Trapping - Insights from CT and in Vivo Lung Morphometry with Hyperpolarized 3He MRI.
Yablonskiy DA, Sukstansky AL, Quirk JD, Hall C, Castro M, Gierada D, Curtis V, Kirby M, Hoffman EA, Yusen RD.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Low and Absent Ventilation Percent on 3He MRI and Cardiac Function: The Mesa COPD Study.
Shen W, Sun Y, Balte P,Dashnaw S, Pince M, Hoffman EA, Lo Cascio CM, Kawut SM, Venkatesh B, Lima J, Wild JM, Hughes E, Barr RG.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Percent Emphysema and Longitudinal Changes in Right Ventricular Dimensions: Development of Cor Pulmonale Parvus in the Mesa COPD Study.
Hermann E, Hoffman EA, Lima J, Ambale-Venkatesh B, Watson K, Carr J, Bluemke A, Prince M, Smith B, Kawut SM, Barr RG.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Genomic Signatures of Type 2 and IL-17 inflammation are Associated with Markers of Disease Severity Across Smokers with Preserved Spirometry and Mild/Moderate Airway Obstruction in Spiromics.
Garudadri S, Han MK, Hoffman EA, Barr R, Bleecker ER, Bowler RP, Comellas AP, Cooper CB,
Couper D, Criner GJ, Dransfield MT, Hansel NN, Kanner RE, Paine R, Krishnan JA, Peter SP, Woodruff P, Christenson S.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Aspirin Use in Associated with Reduced Rate of COPD Exacerbations in the SPIROMICS Cohort: A Propensity Score Matched Analysis.
Fawzy A, Putcha N, Aaron CP, Bowler RP, Comellas AP, Cooper CB, Dransfield MT, Han MK, Hoffman EA, Kanner RE, Krishnan JA, Labaki WW, Paulin LM, Peters SP, Wise RA, Barr R, Hansel NN, SPIROMICS Investigators.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Comprehensive Gene Resequencing of SERPINA1 in SPIROMICS Reveals Novel Rare Loci for a1-Antitrypsin Deficiency and Emphysema.
Ortega VE, Hawkins GA, Li X, O'Neal WK, Manichaikul A, Barr R, Cooper CB, Couper D, Curtis JL, Han MK, Hansel NN, Kanner RE,
Martinez FJ, Paine R, Wells JM, Woodruff P, Hoffman EA, Peters SP, Meyers DA, Bleecker ER, NHLBI SPIROMICS.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Genomic and Transcriptomic Analysis of Pulmonary Function and Emphysema on CT Scans.
Manichaikul A, Nguyen JN, Christenson S, Tew W, Neighbors M, Garudadri S, Nerella S, Hoffman EA, Farber CR,
Cho MH, O'Neal Wk, Woodruff P, Wain LV, Rotter JI, London S, Im H, Rich SS, Barr RG.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Xenon-Enhanced CT for Measurement of Regional Gas Transport During Oscillatory Ventilation.
Herrmann J, Reinhardt JM, Hoffman EA, Kaczka DW.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Short Term Reliablity of CAT, mMRC and SGRQ for Identifying "Symptomatic " Smokers Using Established Cutoffs.
Patel S, Anderson WH, Barr R, Barjaktarevic I, Bleecker ER, Bowler RP, Carretta E, Christenson S, Cooper CB, Comellas AP,
Couper D, Criner GJ, Curtis JL, Dransfield MT, Hansel NN, Han MK, Hoffman EA, Kanner RE, Krishnan JA, Lazarus SC, Martinez FJ, Paine R, Woodruff P.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Endothelial and Platelet Activation in the Multi-Ethnic Study of Atheroscierosis (MESA) COPD Study.
Aaron CP, Hoffman EA, Prince MR, Hughes E, Dashnaw S, Lo Cascio CM, Oelsner E, Shen W, Sun Y, Vogel-Claussen J, Wild J, Tracy RP, Barr RG.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

A Computational Model of Lung Tissue Mechanics Representing Physiological Heterogeneity in Density from Medical Imaging Data in Healthy Lungs.
Parisi L, Kumar H, Clark AR, Burrowes KS, Hoffman EA, Hopkins SR, Tawhai MH.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Virtual Reality for the Characterization of Blood Vessel to Airway Geometric Relationships.
Abdelraouf M, Motahari A, Jani A, Guo J, Iyer K, Comellas AP, Saylor M, Barr R, Smith BM, Hoffman EA.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Contribution of Air-Trapped Vs. Non-Air-Trapped Emphysematous Lung Regions to a Link Between CT-Based Metrics and Spirometry.
Motahari A, Barr R, Han MK, Newell JD, Bleecker ER, Comellas AP, Couper D, Hansel NN, Kanner RE, Kazerooni E, Martinez FJ, Rennard SI, Woodruff P, Sieren J, Kirby M, Peterson S, Hoffman EA, SPIROMICS Research Group.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Occupational Exposures Influence CT Imaging Characteristics in the Spiriomics Cohort.
Laulin LM, Smith BM, Koch A, Han MK, Hoffman EA, Martinez C, Ejike CO, Blanc PD, Rous J, Barr RG, Peters SP, Paine R, Pirozzi CS, Cooper CB, Dransfield MT, Comellas AP, Kanner RE, Putcha N, Hansel NN.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

QCT Imaging-Based Clusters of Former Smokers Identify Clinical Phenotypes in the SubPopulations and InteRmediate Outcome Measures in COPD Study.
Choi S, Highighi B, Hoffman EA, Newell JD, Comellas AP, Barr R,Han MK, Cooper CB, O'Neal WK, Woodruff P, Martinez FJ, Bleecker ER, Bowler RP, Krishnan JA, Kanner RE, Paine R, Peters SP, Dransfield MT, Hansel NN, Criner GJ, Couper D, Bhatt SP, Lin C, for the NHLBI SubPopulations and InteRmediate Outcome Measures in COPD Study.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018,
Am J Respir Crit Care Med :XXX; 2018

Bronchodilator Responsiveness in COPD: Results from SPIROMICS.
Barjaktarevic I, Hu S, Couper D, Anderson WH, Kanner RE, Paine R, Kaner RJ, Curtis JL, O'Neal WK, Woodruff P, Postow L, Han MK, Martinez FJ, Barr R, Wells JM,Ortega VE, Hoffman EA, Doerschuk CM, Kim V, Dransfield MT, Bhatt SP, Bhakta NR, Drummond MB, Bowler RP, Criner GJ, Martinez C, Tashkin D, Cooper CB.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Unsupervised Discovery of Spatial informed Lung Texture Pattern (sLTP) for Pulmonary Emphysema Subtypes: The Subpopulations and Intermediate Outcome Measures in COPD Study.
Yang J, Angelini ED, Balte PP, Hoffman EA, Austin JH, Smith BM, Bleecker ER, Bowler RP, Cooper CB, Couper D, Dransfield MT, Han MK, Hnsel NN, Martinez FJ, Paine R, Schroeder JD, Woodruff P, Ortega VE, Laine AF, Barr R.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Heterogeneous Burden of Emphysema and Functional Small Airway Abnormalities in Smokers with FEV1/FVC Ratio Above Lower Limit of Normal but Below 0.7.
Piozzi CS, Gu T, Quibrera P, Carretta E, Han MK, Murray S, Cooper CB,Tashkin DP, Kleerup EC, Hoffman EA, Martinez C, Christenson S,
Hansel NN, Barr R, Bleecker ER, Ortega VE, Martinez FJ, Kanner RE, Paine R.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

CTDPM fSAD Measurements Compared at RV Vs. FRC in a Normal and COPD Population: COPDGene.
Comellas AP, Newell JD, Kirby M, Sieren JP, Peterson S, Hoffman EA.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018,
Am J Respir Crit Care Med :XXX; 2018

Time-Varying Regional Aeration and Strain in the Acutely Injured Lung Assessed with 4-D CT Image Registration.
Herrmann J, Shao W, Reinhardt JM, Hoffman EA, Christenson GE, Kaczka DW.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Acute Exacerbations of Chronic Obstructive Pulmonary Disease are Associated with Incident Hip Fractures in Smokers.
Bon JM, Nouraie S, Smith KJ, Dransfield MT, McDonald MN, Hoffman EA, Newell JD, Comellas AP, Saha P, Bowler RP, Regan EA.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Increased Endothelial Cell Damage and Decreased Endothelial Cell Repair Are implicated in Emphysema Pathogenesis: SPIROMICS Immunophenotyping Sub-Study.
Freeman CM, Hoffman EA, Alikaj H, Stolberg VR, Alexis NE, Bleecker ER, Bowler RP, Christenson S, Comellas AP, Cooper CB, Couper D, Doershuk CM, Han MK, Hansel NN, Hastie AT, Kaner RJ, Martinez FJ, Meyers DA, O'Neal WK, Paine R, Peters SP, Wells JM, Woodruff P, Barr RG, Curtis JL.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Airway Epithelial MicroRNAs Associated with Small Airway Dysfunction and Interleukin-17-Driven Inflammation in Chronic Obstructive Pulmonary Disease.
Bolourchi S, O'Neal Wk, Kaner RJ, Doerschuk CM, Boucher RC, Criner GJ, Couper D, Bowker RP, Comellas AP,
Dransfield MT, Krishnan JA, Barjaktarevic I, Paine R, Bleecker ER, Peters SP, Barr RG, Rennard SI, Raman SM, Hansel NN,
Hoffman EA, Galban CJ, Curtis JL, Freeman Cm, Martinez FJ, Han MK, Christenson S, Woodruff PG, Bhakta NR.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

Associations Between a Genetic Risk Score for COPD Susceptibility and Lung Function and Structure on Computed Tomography in a Multiethnic US Population-Based Sample: The MESA Lung Study.
Oelsner E, Nguyen J, Manichaikul A,Orega VE, Smith BM, Hoffman EA, Guo X, Taylor K, Rich SS, Rotter JI, Barr RG.
American Thoracic Society Annual Meeting, San Diego, CA, May 2018
Am J Respir Crit Care Med :XXX; 2018

ERS

Pulmonary Perfusion Heterogeneity is Reduced with Hyperoxia in Emphysema-Susceptible Smokers.
Iyer KS, Motahari A, Comellas AP, Kacxka DW, Hoffman EA.
ERS International Congress. Paris France. September 2018

SPIE

Topological leakage detection and freeze-and-grow propagation for improved CT-based airway segmentation. Nadeem, S. A., Hoffman, E. A., Sieren, J. P., & Saha, P. K.
SPIE 2018. In Medical Imaging 2018: Image Processing (Vol. 10133, p. 1013308).
International Society for Optics and Photonics

ATS

Eric Hoffman: Co-Chair of the Mini-Symposium session #1540, entitled, "SEEING IS BELIEVING: USING NOVEL IMAGING
TECHNIQUES TO UNDERSTAND THE LUNG IN HEALTH AND DISEASE"
Location: Independence Ballroom A-D (Level M4), Marriott Marquis Washington
SUNDAY, MAY 21, 2017
2:15-4:15PM

Jiwoong Choi, Ph.D. ID 8237 Cross-Volume and Cross-Time CT Image Matching Assessment Provides Multiscale
Characterization of Individual Asthmatic Lung Responses to Bronchodilator
A98-SEEING IS BELIEVING: USING NOVEL IMAGING TECHNIQUES TO UNDERSTAND THE LUNG IN HEALTH AND DISEASE Mini Symposium
Location: Independence Ballroom A-D (Level M4), Marriott Marquis Washington
SUNDAY, MAY 21, 2017
3:15-3:30 PM

Sandeep Bodduluri, PhD. ID 7087 Weighted Density Difference Between Paired Computed Tomography (CT) Scans As a
Metric of Lung Function to Predict FEV1 Decline in Chronic Obstructive Pulmonary Disease (COPD). (Sandeep Bodduluri,
Joseph M. Reinhardt, Eric A. Hoffman, John D. Newell Jr., Jessica C. Seiren, Mark T. Dransfield, Surya P. Bhatt. )
A103-COPD: DISEASE PROGRESSION AND PROGNOSIS
Poster Discussion Session
Location: Room 209 A-C (South Building, Level 2), Walter E. Washington Convention Center
SUNDAY, MAY 21, 2017
2:15 PM-4:15 PM
Poster discussion: 3:00-4:15PM

Babak Haghighi (Lin's PhD student)
ID 8697 Quantitative Assessment of Multiscale Imaging-Based Structural and Functional Metrics in the Subpopulations
and Intermediate Outcome Measures in COPD Study (SPIROMICS)
A98-SEEING IS BELIEVING: USING NOVEL IMAGING TECHNIQUES TO UNDERSTAND THE LUNG IN HEALTH AND DISEASE
Mini Symposium
Location: Independence Ballroom A-D (Level M4), Marriott Marquis Washington
SUNDAY, MAY 21, 2017
3:45-4:00 PM

Samuel Ash, M.D.: ID 7923; A4867 Associations Between Pruning of the Pulmonary Vasculature, Impaired Lung Function
and Fixed Obstruction in Asthmatics:
The SARP Cohort B109-ADVANCES IN PULMONARY MEASUREMENTS, MODELING, AND METHODOLOGY
Poster Discussion Session
MONDAY, MAY 22, 2017
Location: Marquis Ballroom 1-2 (Level M2), Marriott Marquis Washington
Viewing Time: 2:15-3:00
Discussion Time: 3:00-4:15

Sanghun Choi (Babak Haghighi will present the poster)
ID 8468 Quantitative CT Imaging-Based Characteristics in Asthma and COPD Populations with Chronic Functional Alterations
B109-ADVANCES IN PULMONARY MEASUREMENTS, MODELING, AND METHODOLOGY
Poster Discussion Session
MONDAY, MAY 22, 2017
Location: Marquis Ballroom 1-2 (Level M2), Marriott Marquis Washington
2:15 PM-3:00 PM
Discussion Time: 3:00-4:15

Jiwoong Choi, Ph.D. Co-Facilitator of the Thematic Poster Session
B80-C-GETTING MODELED: BIOENGINEERING AND COMPUTATIONAL METHODS
Monday, May 22, 2017
Location: Area E, Hall B-C (Middle Building, Lower Level), Walter E. Washington Convention Center
9:15 AM-4:15 PM
Poster Viewing Time: 11:15-1:00

Sandeep Bodduluri, PhD. ID 7047 A Simple Global Measure of Functional Small Airway Disease (fSAD) in Chronic
Obstructive Pulmonary Disease (COPD): A "Density-Mask" Based Approach
C22-COPD PHENOTYPES
Poster Discussion Session
TUESDAY, MAY 23, 2017
Room 209 A-C (South Building, Level 2), Walter E. Washington Convention Center
Poster viewing: 9:15-10:00
Poster discussion: 10:00-11:15AM

Amin Motahari, Ph.D; ID 8349 Effect of CT Reconstructed Field of View on Quantitative Airway Measurements
C80-C-IMAGING METHODOLOGY AND APPLICATION TO LUNG DISEASE
Thematic Poster Session
TUESDAY, MAY 23, 2017
Location: Area N, Hall B-C (Middle Building, Lower Level), Walter E. Washington Convention Center
Poster viewing: 11:15-1:00PM

Amin Motahari, Ph.D ; ID 8351 Short Term Repeatability of CT-Derived Pulmonary Airway and Density Measures:
Role of Quality Control Measures in Assuring Measurement Reliability.
SPIROMICS C80-C-IMAGING METHODOLOGY AND APPLICATION TO LUNG DISEASE
Thematic Poster Session
TUESDAY, MAY 23, 2017
Location: Area N, Hall B-C (Middle Building, Lower Level), Walter E. Washington Convention Center
Poster viewing: 11:15-1:00PM

Emily Hammond, Ph.D.; ID 8350 Development of A Lung Cancer Pig Model: Non-Invasive Characterization with Computed
Tomography (Emily Hammond, Dawn E. Quelle, Mahmoud H. Abou Alaiwa, Kelly Stark, Melissa Saylor,
Shayna Hogue, Frank Rohret, John D. Newell Jr., Ryan M. Sheehy, Ume Salma S., David K. Meyerholz, Benjamin Darbro,
Christopher S. Rogers, Jessica C. Sieren)
C80-C-IMAGING METHODOLOGY AND APPLICATION TO LUNG DISEASE
Thematic Poster Session
TUESDAY, MAY 23, 2017
Location: Area N, Hall B-C (Middle Building, Lower Level), Walter E. Washington Convention Center
Poster viewing: 11:15-1:00PM

Johanna Uthoff; ID 10601 Imaging Feature Reduction and Optimization: Refinement of a Lung Nodule Computer Aided
Diagnosis Tool (Johanna Uthoff B.S.E., Samantha K. N. Dilger Ph.D., Jessica C. Sieren, Ph.D. )
C80-C-IMAGING METHODOLOGY AND APPLICATION TO LUNG DISEASE
Thematic Poster Session
TUESDAY, MAY 23, 2017
Location: Area N, Hall B-C (Middle Building, Lower Level), Walter E. Washington Convention Center
Poster viewing: 11:15-1:00PM

Jake Herrmann; A6522 - Temporally-Resolved Computed Tomographic (CT) Imaging to Assess Regional Parenchymal Strain
During Oscillatory Ventilation. (: J. Herrmann1, M.K. Fuld2, E.A. Hoffman3, D.W. Kaczka)
C80-C-IMAGING METHODOLOGY AND APPLICATION TO LUNG DISEASE
Thematic Poster Session
Tuesday, May 23, 2017
Location: Area N, Hall B-C (Middle Building, Lower Level), Walter E. Washington Convention Center
Poster viewing: 11:15-1:00PM

Eric A. Hoffman, Ph.D.; presentation
"Recent Advances in CT Quantification of Vascular Pathology in COPD"
C92 - STATE OF THE ART ON THORACIC IMAGING AND RADIOGRAPHIC METRICS IN THE QUANTIFICATION OF LUNG DISEASE
Location: Marquis Ballroom 6 (Level M2), Marriott Marquis Washington
3:55pm-4:15pm

David Kaczka: Chair of session D109-UNDERSTANDING THE MECHANISMS OF ACUTE LUNG INJURY
Poster Discussion Session
Wednesday, May 24, 2017
Location: Marquis Ballroom 1-2 (Level M2), Marriott Marquis Washington
1:30 PM-3:30 PM